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鏂扮檪娉曞伐浣滃師鐞�
閱�(y墨)瀛�(xu茅)鍗氬＋Emese Zsiros鏄疪oswell Park濠︾鑵槫绉戝拰鍏嶇柅娌荤檪涓績鐨勪竴鍚嶉啱(y墨)鐢熷拰鏁欏摗锛屼粬鎸囧嚭锛屽皣閫欏叐绋唬娉涗娇鐢ㄧ殑鍏ㄨ韩鍖栫檪钘ョ墿鑸噋embrolizumab锛堜竴绋厤鐤鏌ラ粸(di菐n)鎶戝埗鍔戯級鐩哥祼(ji茅)鍚堢殑鎯虫硶锛屾簮浜庢敼鍠勫厤鐤弽鎳�(y墨ng)鍚屾檪(sh铆)淇濇寔鐢熸椿璩�(zh矛)閲忕殑鎰挎湜銆�
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鑱�(li谩n)鍚堟柟妗堢殑鎮ｈ€呮湁椤憲鐨勭泭铏�
瑭插皬绲勭殑绗�2闅庢鑷ㄥ簥鐮旂┒绲�(ji茅)鏋滆〃鏄�锛屾帴鍙楅€欑ó鑱�(li谩n)鍚堟柟妗堢殑鎮ｈ€呮湁椤憲鐨勭泭铏�銆�
鍦�40渚嬪京(f霉)鐧�(f膩)鎴栭洠娌绘€у嵉宸㈢檶銆佽几鍗电鐧屾垨鑵硅啘鐧岀殑鎮ｈ€呬腑锛�95%鐨勬偅鑰呭緸閫欑ó娌荤檪涓嵅寰椾簡鑷ㄥ簥鐩婅檿銆傜劇(w煤)閫�(j矛n)灞曠敓瀛樻湡骞句箮缈讳簡涓€鐣�锛屽緸5-6鍊�(g猫)鏈堢殑闋�(y霉)鏈熺敓瀛樻湡澧炲姞鍒�10鍊�(g猫)鏈堛€傞€欑ó绲勫悎鐢�(ch菐n)鐢熶簡鎸佷箙鐨勫弽鎳�(y墨ng)锛�47.5%鐨勫彈瑭﹁€呭皪(du矛)娌荤檪鏈夊弽鎳�(y墨ng)锛�25%鐨勬偅鑰呰〃鐝�(xi脿n)鍑洪暦(zh菐ng)鏈熺殑鐤剧梾鎺у埗銆�
鐮旂┒灏忕祫鍦ㄥ咕鍊�(g猫)闂�(gu膩n)閸垫檪(sh铆)鍒昏⿻(p铆ng)浼颁簡鍙冭垏鑰呯殑鐢熸椿璩�(zh矛)閲�銆傜爺绌朵腑鐨勬偅鑰呭湪鏁村€�(g猫)鐮旂┒閬�(gu貌)绋嬩腑淇濇寔浜嗛珮姘村钩鍜岀┅(w臎n)瀹氭€�銆備竴浜涙寚妯�(bi膩o)-锛涜韩楂斿舰璞″拰鎯呮劅/绀炬渻(hu矛)鍔熻兘-锛涘(sh铆)闅涗笂鍦ㄦ暣鍊�(g猫)瑭﹂(y脿n)閬�(gu貌)绋嬩腑寰楀埌浜嗘敼鍠勩€�
Zsiros鍗氬＋瑾�(shu艒)锛�“鍙冨姞閫欓爡(xi脿ng)鑷ㄥ簥瑭﹂(y脿n)鐨勬偅鑰呯殑鐢熸椿璩�(zh矛)閲忛潪甯稿ソ銆備粬鍊戜腑鐨勫ぇ澶氭暩(sh霉)浜鸿兘澶犳梾琛�锛岃垏瀹朵汉鍏卞害缇庡ソ鏅�(sh铆)鍏�锛屽苟鎭㈠京(f霉)浠栧€戠殑妤�(y猫)浣欐剾(脿i)濂�——鐑归＊銆佸緬姝ユ梾琛�锛岄€欎簺閮芥槸浠栧€戜互鍓嶆矑(m茅i)鏈夊仛閬�(gu貌)鐨勪簨鎯�銆傚ぇ绱�30%鐨勬偅鑰呭湪鎺ュ彈閫欑ó鑱�(li谩n)鍚堟不鐧傚悗浠嶇劧娲讳簡涓€骞村崐锛岄€欐槸鎴戝€戞矑(m茅i)鏈夐爯(y霉)鏂欏埌鐨�銆傞€欎簺閮芥槸闈炲父椤憲鐨勭祼(ji茅)鏋溿€�”
澶х磩70%鐨勫嵉宸㈢檶鎮ｈ€呮渻(hu矛)寰�(f霉)鐧�(f膩)銆傜爺绌惰〃鏄�锛屽皪(du矛)浜庨偅浜涚檶鐧ュ京(f霉)鐧�(f膩)鐨勬偅鑰�锛屽彲鐢ㄧ殑“浜岀窔”鍖栫檪鑸囨湁闄愮殑鑷ㄥ簥鏁堢泭鐩搁棞(gu膩n)锛岀附鐨勬湁鏁堢巼鍦�10-25%涔嬮枔锛屽苟灏�(d菐o)鑷撮’钁楃殑娌荤檪鐩搁棞(gu膩n)姣掓€с€傚儏鏈�8%鐨勫京(f霉)鐧�(f膩)鎬у嵉宸㈢檶鎮ｈ€呭皪(du矛)鍠敤pembrolizumab鏈夊弽鎳�(y墨ng)銆�
鎰忕京
瑭茶珫鏂囩殑璩囨繁浣滆€匥unle Oduns鍗氬＋瑾�(shu艒)锛�“閫欓爡(xi脿ng)鑷ㄥ簥瑭﹂(y脿n)浠ｈ〃浜嗕娇鐢ㄨ伅(li谩n)鍚堢檪娉曟彁楂樺厤鐤不鐧傛晥鏋滅殑涓€鍊�(g猫)閲嶈姒傚康鎬ч€�(j矛n)灞�锛岃瓑鏄庢垜鍊戝彲浠ュ湪涓嶅奖闊跨敓娲昏唱(zh矛)閲忕殑鎯呮硜涓嬪(sh铆)鐝�(xi脿n)鍗靛发鐧岀殑闀�(zh菐ng)鏈熺柧鐥呮帶鍒�銆�”涓栬(w猫i)绲勭箶鍓富浠�銆佸厤鐤不鐧備腑蹇冨煼(zh铆)琛屼富浠讳互鍙奟oswell Park鐨凪.Steven Piver濠︾鑵槫瀛�(xu茅)鏁欐巿涔熻〃绀猴細”鍦ㄦ垜鍊戠殑瑭﹂(y脿n)涓⿻(p铆ng)浼扮殑鑱�(li谩n)鍚堟柟妗堟槸涓€绋皪(du矛)寰�(f霉)鐧�(f膩)鎬у嵉宸㈢檶鎮ｈ€呮噳(y墨ng)鑰冩叜鐨勯伕鎿囷紝鍥�?y脿n)妯楊弶鍝傛噲鍙ㄩ箠鍝お鑻勯櫌铔�?qi谩ng)鐑堢殑鐧傛晥淇¤櫉(h脿o)銆�”
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